Jump to ContentJump to Main Navigation
The Origins of Schizophrenia$
Users without a subscription are not able to see the full content.

Alan Brown and Paul Patterson

Print publication date: 2011

Print ISBN-13: 9780231151245

Published to Columbia Scholarship Online: November 2015

DOI: 10.7312/columbia/9780231151245.001.0001

Show Summary Details
Page of

PRINTED FROM COLUMBIA SCHOLARSHIP ONLINE (www.columbia.universitypressscholarship.com). (c) Copyright University of Minnesota Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in CUPSO for personal use.date: 25 July 2021

Animal Models of the Maternal Infection Risk Factor for Schizophrenia

Animal Models of the Maternal Infection Risk Factor for Schizophrenia

(p.255) Chapter 10 Animal Models of the Maternal Infection Risk Factor for Schizophrenia
The Origins of Schizophrenia

Paul H. Patterson

Columbia University Press

This chapter presents animal experiments that study maternal infection as a risk factor for schizophrenia. Exposure of pregnant mice to a strain of human influenza virus results in offspring with several histologic abnormalities in the hippocampus and cortex. These offspring also display a spatially restricted deficit in Purkinje cells, which are commonly found in autism and also occur in schizophrenia, as well as smaller and more densely packed pyramidal cells, a finding also reminiscent of schizophrenia pathology. Moreover, rodent models of viral and bacterial maternal infection yield offspring with a series of abnormal behaviors and neuropathology consistent with those found in schizophrenia. These models are being used to investigate the molecular and cellular pathways that mediate the effects of maternal infection on fetal brain development.

Keywords:   maternal infection, schizophrenia, hippocampus, cortex, Purkinje cells, neuropathology

Columbia Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs, and if you can't find the answer there, please contact us .