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The Origins of Schizophrenia$
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Alan Brown and Paul Patterson

Print publication date: 2011

Print ISBN-13: 9780231151245

Published to Columbia Scholarship Online: November 2015

DOI: 10.7312/columbia/9780231151245.001.0001

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Animal Models of the Maternal Infection Risk Factor for Schizophrenia

Animal Models of the Maternal Infection Risk Factor for Schizophrenia

Chapter:
(p.255) Chapter 10 Animal Models of the Maternal Infection Risk Factor for Schizophrenia
Source:
The Origins of Schizophrenia
Author(s):

Paul H. Patterson

Publisher:
Columbia University Press
DOI:10.7312/columbia/9780231151245.003.0010

This chapter presents animal experiments that study maternal infection as a risk factor for schizophrenia. Exposure of pregnant mice to a strain of human influenza virus results in offspring with several histologic abnormalities in the hippocampus and cortex. These offspring also display a spatially restricted deficit in Purkinje cells, which are commonly found in autism and also occur in schizophrenia, as well as smaller and more densely packed pyramidal cells, a finding also reminiscent of schizophrenia pathology. Moreover, rodent models of viral and bacterial maternal infection yield offspring with a series of abnormal behaviors and neuropathology consistent with those found in schizophrenia. These models are being used to investigate the molecular and cellular pathways that mediate the effects of maternal infection on fetal brain development.

Keywords:   maternal infection, schizophrenia, hippocampus, cortex, Purkinje cells, neuropathology

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