Jump to ContentJump to Main Navigation
The Origins of Schizophrenia$
Users without a subscription are not able to see the full content.

Alan Brown and Paul Patterson

Print publication date: 2011

Print ISBN-13: 9780231151245

Published to Columbia Scholarship Online: November 2015

DOI: 10.7312/columbia/9780231151245.001.0001

Show Summary Details
Page of

PRINTED FROM COLUMBIA SCHOLARSHIP ONLINE (www.columbia.universitypressscholarship.com). (c) Copyright University of Minnesota Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in CUPSO for personal use.date: 26 July 2021

Developmental Vitamin D Deficiency as a Risk Factor for Schizophrenia

Developmental Vitamin D Deficiency as a Risk Factor for Schizophrenia

Chapter:
(p.282) Chapter 11 Developmental Vitamin D Deficiency as a Risk Factor for Schizophrenia
Source:
The Origins of Schizophrenia
Author(s):

Xiaoying Cui

Darryl W. Eyles

Thomas H. J. Burne

John J. Mcgrath

Publisher:
Columbia University Press
DOI:10.7312/columbia/9780231151245.003.0011

This chapter discusses developmental vitamin D (DVD) deficiency as a potential risk factor for schizophrenia. Over the last decade, evidence has accumulated demonstrating that vitamin D plays an important role in brain development; hence, vitamin D deficiency may result in a higher risk for schizophrenia. Scientist conducted an experiment on rats to demonstrate how DVD deficiency can alter neurobiological features, which are consistent with that of schizophrenia. The finding shows that DVD deficient rats had cerebral hemispheres that were longer but not wider than common rats, and increased mitosis across the embryonic brain. These results suggest that vitamin D exerts a pro-differentiation and pro-apoptotic function in the developing brain. The altered brain size and shape in DVD-deficient rats may be the result of the disrupted normal progression of brain cells.

Keywords:   developmental vitamin D deficiency, schizophrenia, cerebral hemispheres, rats

Columbia Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs, and if you can't find the answer there, please contact us .