Jump to ContentJump to Main Navigation
The Origins of Schizophrenia$
Users without a subscription are not able to see the full content.

Alan Brown and Paul Patterson

Print publication date: 2011

Print ISBN-13: 9780231151245

Published to Columbia Scholarship Online: November 2015

DOI: 10.7312/columbia/9780231151245.001.0001

Show Summary Details
Page of

PRINTED FROM COLUMBIA SCHOLARSHIP ONLINE (www.columbia.universitypressscholarship.com). (c) Copyright University of Minnesota Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in CUPSO for personal use.date: 26 July 2021

Animal Models of Prenatal Protein Malnutrition Relevant for Schizophrenia

Animal Models of Prenatal Protein Malnutrition Relevant for Schizophrenia

Chapter:
(p.300) Chapter 12 Animal Models of Prenatal Protein Malnutrition Relevant for Schizophrenia
Source:
The Origins of Schizophrenia
Author(s):

Lisa M. Tarantino

Teresa M. Reyes

Abraham A. Palmer

Publisher:
Columbia University Press
DOI:10.7312/columbia/9780231151245.003.0012

This chapter presents animal models for prenatal protein malnutrition to discuss its relevance to schizophrenia. Protein deprivation during fetal development causes lasting changes in brain regions implicated in learning and memory. Also, the lack of protein during that period may result in behavioral, structural, and neurochemical changes in adulthood that mimic many of the characteristics of psychiatric diseases, including schizophrenia. Animal models have been used extensively to study the effects of protein malnutrition. One of the simplest assessments of sensory and cognitive development is the homing test, in which suckling animals are tested for their ability to locate the nest after displacement. Data consistently shows that protein-malnourished animals do not have the ability to return to their nest. Moreover, protein deprivation in utero or during the suckling period causes significant hippocampal alterations, including long-term potentiation deficits.

Keywords:   animal models, protein, schizophrenia, hippocampal, displacement

Columbia Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs, and if you can't find the answer there, please contact us .