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The Origins of Schizophrenia$
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Alan Brown and Paul Patterson

Print publication date: 2011

Print ISBN-13: 9780231151245

Published to Columbia Scholarship Online: November 2015

DOI: 10.7312/columbia/9780231151245.001.0001

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PRINTED FROM COLUMBIA SCHOLARSHIP ONLINE (www.columbia.universitypressscholarship.com). (c) Copyright University of Minnesota Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in CUPSO for personal use.date: 22 September 2021

Animal Models of the Maternal Stress Risk Factor for Schizophrenia

Animal Models of the Maternal Stress Risk Factor for Schizophrenia

Chapter:
(p.335) Chapter 13 Animal Models of the Maternal Stress Risk Factor for Schizophrenia
Source:
The Origins of Schizophrenia
Author(s):

Paul H. Patterson

Publisher:
Columbia University Press
DOI:10.7312/columbia/9780231151245.003.0013

This chapter examines animal models for maternal stress to discuss its risk factors for schizophrenia. Epidemiologic evidence implicates maternal stress as a risk factor for schizophrenia in the offspring. Research shows that in a variety of mammalian species, the offspring of stressed mothers display numerous altered behaviors, such as increased immobility in the forced swim test, deficits in learning, and depressive-like conduct. Many of these behaviors are associated with disturbance of the hypothalamic pituitary-adrenal axis and are found in human major depressive disorder and schizophrenia. Studies found that Stress-induced elevation of maternal glucocorticoid levels is a major factor in altering fetal brain and placenta.

Keywords:   maternal stress, schizophrenia, forced swim test, fetal brain, placenta

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