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The Origins of Schizophrenia$
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Alan Brown and Paul Patterson

Print publication date: 2011

Print ISBN-13: 9780231151245

Published to Columbia Scholarship Online: November 2015

DOI: 10.7312/columbia/9780231151245.001.0001

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Animal Models of the Maternal Stress Risk Factor for Schizophrenia

Animal Models of the Maternal Stress Risk Factor for Schizophrenia

(p.335) Chapter 13 Animal Models of the Maternal Stress Risk Factor for Schizophrenia
The Origins of Schizophrenia

Paul H. Patterson

Columbia University Press

This chapter examines animal models for maternal stress to discuss its risk factors for schizophrenia. Epidemiologic evidence implicates maternal stress as a risk factor for schizophrenia in the offspring. Research shows that in a variety of mammalian species, the offspring of stressed mothers display numerous altered behaviors, such as increased immobility in the forced swim test, deficits in learning, and depressive-like conduct. Many of these behaviors are associated with disturbance of the hypothalamic pituitary-adrenal axis and are found in human major depressive disorder and schizophrenia. Studies found that Stress-induced elevation of maternal glucocorticoid levels is a major factor in altering fetal brain and placenta.

Keywords:   maternal stress, schizophrenia, forced swim test, fetal brain, placenta

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