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The Origins of Schizophrenia$
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Alan Brown and Paul Patterson

Print publication date: 2011

Print ISBN-13: 9780231151245

Published to Columbia Scholarship Online: November 2015

DOI: 10.7312/columbia/9780231151245.001.0001

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Mutant Models of Nrg1 and ErbB4

Mutant Models of Nrg1 and ErbB4

Abnormalities of Brain Structures, Functions, and Behaviors Relevant to Schizophrenia

(p.382) Chapter 15 Mutant Models of Nrg1 and ErbB4
The Origins of Schizophrenia

Yachi Chen

Lorna W. Role

David A. Talmage

Columbia University Press

This chapter presents animal models for Nrg1 and ErbB4 to explain their role in schizophrenia. Multiple studies provide evidence that NRG1 and ERBB4 are candidate susceptibility genes for schizophrenia. Mice with genetic disruption in Nrg1 or ErbB4 display enlarged lateral ventricles and reduced spine density on hippocampal subicular dendrites, which are characteristics of schizophrenia neuropathology. Nrg1 and ErbB4 mutant mice also display hyperlocomotor activity, impaired sensorimotor gating, abnormal social interactions, and diminished performance in learning and memory tasks. The findings concerning these transgenic mice that model alterations in schizophrenia should aid significantly the understanding of the etiology and pathophysiology of the disease.

Keywords:   schizophrenia, Nrg1, ErbB4, subicular dendrites, pathophysiology

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