Jump to ContentJump to Main Navigation
The Origins of Schizophrenia$
Users without a subscription are not able to see the full content.

Alan Brown and Paul Patterson

Print publication date: 2011

Print ISBN-13: 9780231151245

Published to Columbia Scholarship Online: November 2015

DOI: 10.7312/columbia/9780231151245.001.0001

Show Summary Details
Page of

PRINTED FROM COLUMBIA SCHOLARSHIP ONLINE (www.columbia.universitypressscholarship.com). (c) Copyright University of Minnesota Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in CUPSO for personal use.date: 25 July 2021

Mutant Models of Nrg1 and ErbB4

Mutant Models of Nrg1 and ErbB4

Abnormalities of Brain Structures, Functions, and Behaviors Relevant to Schizophrenia

Chapter:
(p.382) Chapter 15 Mutant Models of Nrg1 and ErbB4
Source:
The Origins of Schizophrenia
Author(s):

Yachi Chen

Lorna W. Role

David A. Talmage

Publisher:
Columbia University Press
DOI:10.7312/columbia/9780231151245.003.0015

This chapter presents animal models for Nrg1 and ErbB4 to explain their role in schizophrenia. Multiple studies provide evidence that NRG1 and ERBB4 are candidate susceptibility genes for schizophrenia. Mice with genetic disruption in Nrg1 or ErbB4 display enlarged lateral ventricles and reduced spine density on hippocampal subicular dendrites, which are characteristics of schizophrenia neuropathology. Nrg1 and ErbB4 mutant mice also display hyperlocomotor activity, impaired sensorimotor gating, abnormal social interactions, and diminished performance in learning and memory tasks. The findings concerning these transgenic mice that model alterations in schizophrenia should aid significantly the understanding of the etiology and pathophysiology of the disease.

Keywords:   schizophrenia, Nrg1, ErbB4, subicular dendrites, pathophysiology

Columbia Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs, and if you can't find the answer there, please contact us .