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The Origins of Schizophrenia$
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Alan Brown and Paul Patterson

Print publication date: 2011

Print ISBN-13: 9780231151245

Published to Columbia Scholarship Online: November 2015

DOI: 10.7312/columbia/9780231151245.001.0001

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Obstetric Complications and Schizophrenia

Obstetric Complications and Schizophrenia

Historical Overview and New Directions

Chapter:
(p.96) Chapter 3 Obstetric Complications and Schizophrenia
Source:
The Origins of Schizophrenia
Author(s):

Mary Clarke

Sarah Roddy

Mary Cannon

Publisher:
Columbia University Press
DOI:10.7312/columbia/9780231151245.003.0003

This chapter provides evidence proving that obstetric complications may result in a higher risk of schizophrenia in offspring. These complications may include bleeding, preeclampsia, maternal diabetes, rhesus incompatibility, maternal nonattendance of antenatal appointments, and threatened premature delivery. These conditions could result in de novo mutations in genes critical for brain development, either in somatic or germ-line cells. Although scientists are now beginning to map out the genes that play important roles during neurodevelopment in animal models, it seems clear that the genetic loci involved are both numerous and diverse in terms of function. There is also evidence that obstetric complications may have synergistic effects with other schizophrenia risk factors.

Keywords:   obstetric complication, schizophrenia, brain development, rhesus incompatibility, maternal diabetes, preeclampsia

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