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The Origins of Schizophrenia$
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Alan Brown and Paul Patterson

Print publication date: 2011

Print ISBN-13: 9780231151245

Published to Columbia Scholarship Online: November 2015

DOI: 10.7312/columbia/9780231151245.001.0001

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PRINTED FROM COLUMBIA SCHOLARSHIP ONLINE (www.columbia.universitypressscholarship.com). (c) Copyright University of Minnesota Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in CUPSO for personal use.date: 22 September 2021

Obstetric Complications and Schizophrenia

Obstetric Complications and Schizophrenia

Historical Overview and New Directions

(p.96) Chapter 3 Obstetric Complications and Schizophrenia
The Origins of Schizophrenia

Mary Clarke

Sarah Roddy

Mary Cannon

Columbia University Press

This chapter provides evidence proving that obstetric complications may result in a higher risk of schizophrenia in offspring. These complications may include bleeding, preeclampsia, maternal diabetes, rhesus incompatibility, maternal nonattendance of antenatal appointments, and threatened premature delivery. These conditions could result in de novo mutations in genes critical for brain development, either in somatic or germ-line cells. Although scientists are now beginning to map out the genes that play important roles during neurodevelopment in animal models, it seems clear that the genetic loci involved are both numerous and diverse in terms of function. There is also evidence that obstetric complications may have synergistic effects with other schizophrenia risk factors.

Keywords:   obstetric complication, schizophrenia, brain development, rhesus incompatibility, maternal diabetes, preeclampsia

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