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The Origins of Schizophrenia$
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Alan Brown and Paul Patterson

Print publication date: 2011

Print ISBN-13: 9780231151245

Published to Columbia Scholarship Online: November 2015

DOI: 10.7312/columbia/9780231151245.001.0001

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PRINTED FROM COLUMBIA SCHOLARSHIP ONLINE (www.columbia.universitypressscholarship.com). (c) Copyright University of Minnesota Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in CUPSO for personal use.date: 22 September 2021

Maternal Stress During Pregnancy and Schizophrenia

Maternal Stress During Pregnancy and Schizophrenia

(p.120) Chapter 4 Maternal Stress During Pregnancy and Schizophrenia
The Origins of Schizophrenia

Mary C. Iampietro

Lauren M. Ellman

Columbia University Press

This chapter discusses the relationship between maternal stress during pregnancy and the increased risk of schizophrenia in offspring. Evidence suggests that maternal emotional and psychosocial distress during pregnancy can affect fetal development and subsequent neurodevelopmental sequelae in offspring. A number of studies show that the children of women who experience war or natural disasters during their first and second trimesters have higher risk for schizophrenia. The second-trimester finding appears to be restricted to males, suggesting that male fetuses may be particularly vulnerable to maternal stress. Maternal stress during pregnancy may also result in childhood cognitive, social, and emotional disturbances that commonly occur during the pre-morbid period of schizophrenia.

Keywords:   maternal stress, schizophrenia, offspring, fetus, pregnancy

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