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The Origins of Schizophrenia$
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Alan Brown and Paul Patterson

Print publication date: 2011

Print ISBN-13: 9780231151245

Published to Columbia Scholarship Online: November 2015

DOI: 10.7312/columbia/9780231151245.001.0001

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PRINTED FROM COLUMBIA SCHOLARSHIP ONLINE (www.columbia.universitypressscholarship.com). (c) Copyright University of Minnesota Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in CUPSO for personal use.date: 25 July 2021

Advancing Paternal Age and the Risk for Schizophrenia

Advancing Paternal Age and the Risk for Schizophrenia

(p.140) Chapter 5 Advancing Paternal Age and the Risk for Schizophrenia
The Origins of Schizophrenia

Sarah Crystal

Karine Kleinhaus

Mary Perrin

Dolores Malaspina

Columbia University Press

This chapter presents studies concerning the relationship between advanced paternal age and the risk of schizophrenia. Epidemiologic studies show an increasing risk of schizophrenia due to advancing paternal age. A large prospective cohort study in Jerusalem reported that the risk of schizophrenia doubled with each 10-year increment of paternal age. Several approaches have been employed to examine the biological plausibility of paternal age as a risk factor for schizophrenia. First, animal models were used to examine whether paternal age is related to specific outcomes that are relevant to the mental disorder. Second, epidemiologic studies have examined whether advanced paternal age is related to specific cognitive or social deficits in offspring. Current findings on the relationship between paternal age and schizophrenia suggest new directions for research into the origin of the disease.

Keywords:   paternal age, schizophrenia, epidemiologic studies, animal models, mental disorder

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