What Have We Learned from Genomewide Association Studies?
This chapter discusses new developments in the study of schizophrenia conducted by Genomewide Association Studies. Genomewide experiments are bringing about major conceptual changes in the understanding of the genetics of schizophrenia. Their studies show that schizophrenia and bipolar disorder share several characteristics such as peak onset in early adulthood, psychotic symptoms, response to antipsychotic medications, substance use comorbidity, increased suicide risk, and severe mood episodes. The largest family study found familial co-aggregation between schizophrenia and bipolar disorder to be roughly 63% because of additive genetic effects common to both disorders. Schizophrenia and autism also share a few clinical features such as impaired social interaction and communication, and some negative or deficit symptoms. A study of 129 adults with autism spectrum disorders (ASD) found that 7% had psychotic bipolar disorder and 8% had schizophrenia or other psychotic disorders.
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