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The Origins of Schizophrenia$
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Alan Brown and Paul Patterson

Print publication date: 2011

Print ISBN-13: 9780231151245

Published to Columbia Scholarship Online: November 2015

DOI: 10.7312/columbia/9780231151245.001.0001

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PRINTED FROM COLUMBIA SCHOLARSHIP ONLINE (www.columbia.universitypressscholarship.com). (c) Copyright University of Minnesota Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in CUPSO for personal use.date: 22 September 2021

Schizophrenia Genetics

Schizophrenia Genetics

What Have We Learned from Genomewide Association Studies?

(p.175) Chapter 7 Schizophrenia Genetics
The Origins of Schizophrenia

Alan R. Sanders

Jubao Duan

Pablo V. Gejman

Columbia University Press

This chapter discusses new developments in the study of schizophrenia conducted by Genomewide Association Studies. Genomewide experiments are bringing about major conceptual changes in the understanding of the genetics of schizophrenia. Their studies show that schizophrenia and bipolar disorder share several characteristics such as peak onset in early adulthood, psychotic symptoms, response to antipsychotic medications, substance use comorbidity, increased suicide risk, and severe mood episodes. The largest family study found familial co-aggregation between schizophrenia and bipolar disorder to be roughly 63% because of additive genetic effects common to both disorders. Schizophrenia and autism also share a few clinical features such as impaired social interaction and communication, and some negative or deficit symptoms. A study of 129 adults with autism spectrum disorders (ASD) found that 7% had psychotic bipolar disorder and 8% had schizophrenia or other psychotic disorders.

Keywords:   Genomewide Association Studies, schizophrenia, bipolar disorder, autism spectrum disorders, genetics

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