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The Origins of Schizophrenia

Alan Brown and Paul Patterson

Abstract

This book synthesizes key findings on a devastating mental disorder that has been increasingly studied over the past decade: namely, schizophrenia. Advances in epidemiology, translational neuroscience technology, and molecular and statistical genetics have recast schizophrenia's neurobiological nature, identifying new putative environmental risk factors and candidate susceptibility genes. Providing the latest clinical and neuroscience research developments, this book provides a balanced account, while pointing to future directions in research and interdisciplinary collaboration. The book exami ... More

Keywords: mental disorder, epidemiology, translational neuroscience technology, molecular genetics, statistical genetics, schizophrenia, environmental risk factors, susceptibility genes

Bibliographic Information

Print publication date: 2011 Print ISBN-13: 9780231151245
Published to Columbia Scholarship Online: November 2015 DOI:10.7312/columbia/9780231151245.001.0001

Authors

Affiliations are at time of print publication.

Alan Brown, editor

Paul Patterson, editor

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Contents

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Front Matter

Title Pages

Title Pages

Foreword

Acknowledgments

Introduction

Alan S. Brown and Paul H. Patterson

Overview Schizophrenia and the Lifetime Trajectory of Psychotic Illness

John L. Waddington, Robin J. Hennessy, Colm M. P. O’Tuathaigh, Olabisi Owoeye, and Vincent Russell

Part 1 Clinical Research on Risk Factors for Schizophrenia

Section 1 Environmental Factors

Chapter 1 Maternal Infection and Schizophrenia

Alan S. Brown

Chapter 2 Prenatal Nutrition and the Etiology of Schizophrenia

Kristin N. Harper, and Alan S. Brown

Chapter 3 Obstetric Complications and Schizophrenia

Mary Clarke, Sarah Roddy, and Mary Cannon

Chapter 4 Maternal Stress During Pregnancy and Schizophrenia

Mary C. Iampietro and Lauren M. Ellman

Chapter 5 Advancing Paternal Age and the Risk for Schizophrenia

Sarah Crystal, Karine Kleinhaus, Mary Perrin, and Dolores Malaspina

Chapter 6 Cannabis Use as a Component Cause of Schizophrenia

Paola Casadio, Marta Di Forti, and Robin M. Murray

Section 2 Genetics and Epigenetics

Chapter 7 Schizophrenia Genetics

Alan R. Sanders, Jubao Duan, and Pablo V. Gejman

Chapter 8 Genetic Architecture of Schizophrenia

Maria Karayiorgou, Rebecca J. Levy, and Bin Xu

Chapter 9 The Epigenetics of Schizophrenia

Iris Cheung, Mira Jakovcevski, and Schahram Akbarian

Part 2 Preclinical Research on Etiologies of Schizophrenia

Section 1 Animal Models of Environmental Factors and Schizophrenia

Chapter 10 Animal Models of the Maternal Infection Risk Factor for Schizophrenia

Paul H. Patterson

Chapter 11 Developmental Vitamin D Deficiency as a Risk Factor for Schizophrenia

Xiaoying Cui, Darryl W. Eyles, Thomas H. J. Burne, and John J. Mcgrath

Chapter 12 Animal Models of Prenatal Protein Malnutrition Relevant for Schizophrenia

Lisa M. Tarantino, Teresa M. Reyes, and Abraham A. Palmer

Chapter 13 Animal Models of the Maternal Stress Risk Factor for Schizophrenia

Paul H. Patterson

Section 2 Animal Models of Genetic Factors and Schizophrenia

Chapter 14 DISC1

David Porteous

Chapter 15 Mutant Models of Nrg1 and ErbB4

Yachi Chen, Lorna W. Role, and David A. Talmage

End Matter

Contributors

Index