Jump to ContentJump to Main Navigation
The Quest for the CureThe Science and Stories Behind the Next Generation of Medicines$
Users without a subscription are not able to see the full content.

Brent Stockwell

Print publication date: 2013

Print ISBN-13: 9780231152136

Published to Columbia Scholarship Online: November 2015

DOI: 10.7312/columbia/9780231152136.001.0001

Show Summary Details
Page of

PRINTED FROM COLUMBIA SCHOLARSHIP ONLINE (www.columbia.universitypressscholarship.com). (c) Copyright University of Minnesota Press, 2019. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in CUPSO for personal use.date: 20 October 2019

From Protein-Protein Interactions to Personalized Medicines

From Protein-Protein Interactions to Personalized Medicines

(p.156) 9 From Protein-Protein Interactions to Personalized Medicines
The Quest for the Cure

Brent R. Stockwell

Columbia University Press

This chapter examines how personalized medicines can be developed by controlling protein-protein interactions. For many years, the possibility of targeting protein-protein interactions with drugs seemed fanciful at best, and most researchers viewed such a goal as being impossible. In 1957, however, James Bertram Collip isolated a new molecule named vinblastine from the Madagascar periwinkle plant. Shortly thereafter, Gordon Svoboda at Eli Lilly was able to isolate a similar natural product known as vincristine. Before long, the first cancer patients were treated with these new molecules, and their tumors responded favorably. Vincristine and vinblastine were developed into standard treatments for a variety of cancers, despite their side effects. This chapter looks at the research on protein-protein interactions carried out by James Wells and Tim Clackson during the mid-1990s, the discovery of ligase proteins, and whether it is possible to inhibit any of the 600-plus ligases encoded in the human genome. It also assesses the challenge of blocking protein-protein interactions using small molecules.

Keywords:   personalized medicine, protein-protein interactions, drugs, vinblastine, periwinkle, vincristine, cancer, ligases, small molecules, proteins

Columbia Scholarship Online requires a subscription or purchase to access the full text of books within the service. Public users can however freely search the site and view the abstracts and keywords for each book and chapter.

Please, subscribe or login to access full text content.

If you think you should have access to this title, please contact your librarian.

To troubleshoot, please check our FAQs, and if you can't find the answer there, please contact us .