This chapter describes the process of vaccine manufacturing. Vaccine manufacture starts with creating the strains of a virus, which are then licensed to a pharmaceutical company in order to determine exactly how much of a vaccine virus should be in the final product, and to prove how many doses of the vaccine are necessary. The company also has to prove that the vaccine does not contain contaminating agents that could infect people, and has to buffer and stabilize the vaccine for the equal distribution of virus throughout the vial. Through concomitant-use studies, the company must also justify that the vaccine is safe, and will not interfere with the immune responses of other vaccines that would be given at the same time.
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