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Vaccines and Your ChildSeparating Fact from Fiction$
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Paul Offit and Charlotte Moser

Print publication date: 2011

Print ISBN-13: 9780231153072

Published to Columbia Scholarship Online: November 2015

DOI: 10.7312/columbia/9780231153072.001.0001

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(p.3) General
Vaccines and Your Child

Paul A. Offit

Charlotte A. Moser

Columbia University Press

This chapter describes the process of vaccine manufacturing. Vaccine manufacture starts with creating the strains of a virus, which are then licensed to a pharmaceutical company in order to determine exactly how much of a vaccine virus should be in the final product, and to prove how many doses of the vaccine are necessary. The company also has to prove that the vaccine does not contain contaminating agents that could infect people, and has to buffer and stabilize the vaccine for the equal distribution of virus throughout the vial. Through concomitant-use studies, the company must also justify that the vaccine is safe, and will not interfere with the immune responses of other vaccines that would be given at the same time.

Keywords:   vaccine, vaccine manufacturing, virus, pharmaceutical company, vaccine virus, concomitant-use studies, immune responses

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