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NeurogastronomyHow the Brain Creates Flavor and Why It Matters$
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Gordon Shepherd

Print publication date: 2013

Print ISBN-13: 9780231159111

Published to Columbia Scholarship Online: November 2015

DOI: 10.7312/columbia/9780231159111.001.0001

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Smell Receptors for Smell Molecules

Smell Receptors for Smell Molecules

(p.47) Chapter Five Smell Receptors for Smell Molecules

Gordon M. Shepherd

Columbia University Press

The sense of smell begins with the action of smell molecules on the receptor molecules in our nose, which in turn are a critical part of the smell and flavor system in the brain. This chapter examines how the critical and fascinating meeting between the molecules that are in our food and those that are in our receptor cells occurs. It discusses the discovery of olfactory receptors and considers evidence supporting the hypothesis that odor determinants interact within a binding pocket in the olfactory receptors. This binding pocket is similar to that of other G-protein coupled receptors (GPCRs), but with a set of critical sites that varies with different receptors and can show graded interactions with the determinants of different odor molecules.

Keywords:   smells, taste, human brain, smell molecules, smell receptors, receptor molecules, olfactory receptors, odor, binding pocket

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