- Title Pages
- Title Pages
- Acknowledgments
- Introduction
- Harnessing Stem Cells for Regenerative Medicine
-
Dialogue 1 Hope -
Dialogue 2 Why is this Cell Different from Other Cells? -
Dialogue 3 The President’s Stem Cells -
Dialogue 4 The Dickey-Wicker Enigma -
Dialogue 5 The Moral Status of Embryos -
Dialogue 6 Creating Good from Immoral Acts -
Dialogue 7 Circumventing Embryocide -
Dialogue 8 My Personalized Beta Cells for Diabetes -
Dialogue 9 Repairing Brain Cells in Stroke Victims -
Dialogue 10 Reversing Macular Degeneration -
Dialogue 11 My Stem Cells, My Cancer -
Dialogue 12 Reprogramming Cells -
Dialogue 13 My Personalized Disease Cells -
Dialogue 14 To Clone or not to Clone -
Dialogue 15 Patenting Human Embryonic Stem Cells is Immoral and Illegal (In Europe) -
Dialogue 16 My Embryo is Auctioned on the Internet -
Dialogue 17 Here Comes the Egg Man -
Dialogue 18 Human-Animal Chimeras and Hybrids -
Dialogue 19 Stem Cell Tourism -
Dialogue 20 Social Media Meet Science Hype -
Dialogue 21 Feminism and the Commercialization of Human Eggs/Embryos -
Dialogue 22 Was My Birth Embryo Me? -
Dialogue 23 Embryos without Ovaries -
Dialogue 24 How My Cells Became Drugs -
Dialogue 25 A Clinical Trial for Paralysis Treatment - Epilogue
- Glossary
- Index
Reprogramming Cells
Reprogramming Cells
- Chapter:
- (p.75) Dialogue 12 Reprogramming Cells
- Source:
- Stem Cell Dialogues
- Author(s):
Sheldon Krimsky
- Publisher:
- Columbia University Press
In this dialogue, Dr. Rebecca Franklin and Dr. Frederick Jones, a stem cell biologist, discuss the prospects of cell reprogramming for producing therapeutic stem cells. The process of reprogramming an adult cell to its pluripotent stem cell origins, sometimes referred to as “dedifferentiation,” creates what are called induced pluripotent stem cells (iPSCs). The first evidence of this type of reprogramming from mouse cells was provided by Shinya Yamanaka and his colleagues at Kyoto University in Japan in 2006. Jones has invested considerable time reprogramming somatic cells to make them into embryonic stem cell-like cells (pluripotency). Franklin questions him about reversing the development of a differentiated cell, drawing on her knowledge of epigenetics and cellular biology. Here they talk about the possibilities for creating iPSCs from somatic cells that are more like their embryonic counterparts; oncogene expression and tumorigenesis in embryonic stem cells; and roadblocks to regenerative medicine involving iPSCs.
Keywords: cell reprogramming, therapeutic stem cells, dedifferentiation, induced pluripotent stem cells, mouse cells, somatic cells, epigenetics, tumorigenesis, embryonic stem cells, regenerative medicine
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- Title Pages
- Title Pages
- Acknowledgments
- Introduction
- Harnessing Stem Cells for Regenerative Medicine
-
Dialogue 1 Hope -
Dialogue 2 Why is this Cell Different from Other Cells? -
Dialogue 3 The President’s Stem Cells -
Dialogue 4 The Dickey-Wicker Enigma -
Dialogue 5 The Moral Status of Embryos -
Dialogue 6 Creating Good from Immoral Acts -
Dialogue 7 Circumventing Embryocide -
Dialogue 8 My Personalized Beta Cells for Diabetes -
Dialogue 9 Repairing Brain Cells in Stroke Victims -
Dialogue 10 Reversing Macular Degeneration -
Dialogue 11 My Stem Cells, My Cancer -
Dialogue 12 Reprogramming Cells -
Dialogue 13 My Personalized Disease Cells -
Dialogue 14 To Clone or not to Clone -
Dialogue 15 Patenting Human Embryonic Stem Cells is Immoral and Illegal (In Europe) -
Dialogue 16 My Embryo is Auctioned on the Internet -
Dialogue 17 Here Comes the Egg Man -
Dialogue 18 Human-Animal Chimeras and Hybrids -
Dialogue 19 Stem Cell Tourism -
Dialogue 20 Social Media Meet Science Hype -
Dialogue 21 Feminism and the Commercialization of Human Eggs/Embryos -
Dialogue 22 Was My Birth Embryo Me? -
Dialogue 23 Embryos without Ovaries -
Dialogue 24 How My Cells Became Drugs -
Dialogue 25 A Clinical Trial for Paralysis Treatment - Epilogue
- Glossary
- Index