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Stem Cell DialoguesA Philosophical and Scientific Inquiry Into Medical Frontiers$
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Sheldon Krimsky

Print publication date: 2015

Print ISBN-13: 9780231167482

Published to Columbia Scholarship Online: November 2015

DOI: 10.7312/columbia/9780231167482.001.0001

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PRINTED FROM COLUMBIA SCHOLARSHIP ONLINE (www.columbia.universitypressscholarship.com). (c) Copyright University of Minnesota Press, 2021. All Rights Reserved. An individual user may print out a PDF of a single chapter of a monograph in CUPSO for personal use.date: 24 July 2021

My Personalized Disease Cells

My Personalized Disease Cells

(p.81) Dialogue 13 My Personalized Disease Cells
Stem Cell Dialogues

Sheldon Krimsky

Columbia University Press

In this dialogue, Dr. Rebecca Franklin is having a conversation with Dr. Leonard Phillips, a pediatric cardiologist, and Dan Henderson, a cell biologist, regarding the promise of the “disease in the dish” approach in speeding up research on many different diseases, leading to faster, more efficient screening of potential drug therapies. Franklin is treating a young child with an unusual arrhythmia, while Henderson is conducting research on cardiac electrolyte abnormalities, one of the causes of arrhythmia. Henderson has embraced using stem cells as a revolutionary approach to evaluating drug therapies for electrolyte abnormalities that have a genetic etiology. Here they talk about research on personalized stem cells; the use of human cell culture as a substitute for animal studies; and the ethics of pretesting a drug on humans and animals.

Keywords:   disease in the dish approach, drug therapies, arrhythmia, research, cardiac electrolyte abnormalities, stem cells, personalized stem cells, human cell culture, animal studies, ethics

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